Objective To study the best drug of preoperative bowel preparation for postoperative protein synthesis for patients with hepatocellular carcinoma (HCC). Method A total of 150 patients with HCC were randomly divided into five groups. Patients in group A were treated with oral sodium phosphate (NaP) , in group B were treated with oral 25% magnesium sulfate, in group C were treated with oral lactulose (group C), in group D were treated with oral polyethylene glycol-electrolyte lavage solution (PEG-ELS), in group E were without any preoperative bowel preparation. Venous blood was collected preoperatively on the 1,3,5 and 7 day after surgery. Serum prealbumin was tested, and the differences between pre-and post-operation as well as among the groups were compared. Result The level of serum prealbumin was significantly lower in group E than that of other four groups on the 3 and 5 day after surgery (P< 0. 05). The serum prealbumin in group C was significantly higher than that of in the other three treated groups since the third postoperative day (P<0. 05). Conclusion Preoperative oral bowel preparation would mitigate the downtrend of the level of serum prealbumin for patients with postoperative HCC. For improving postoperative serum pre-albumin, lactulose is superior to NaP, magnesium sulfate and PEG—ELS.%目的 探讨可促进原发性肝癌术后蛋白合成功能恢复的术前清洁肠道的药物.方法 以150例原发性肝癌患者作为研究对象,随机分为A、B、C、D、E五组,每组30例,于术前1天分别采用磷酸钠盐口服溶液(A组)、25％硫酸镁口服溶液(B组)、乳果糖口服溶液(C组)、聚乙二醇电解质散(D组)进行口服洗肠、E组为空白对照组,术前不进行肠道清洁.比较各组术前及术后第1、3、5、7天血清前白蛋白的水平.结果 术后第3天、第5天,空白对照组血清前白蛋白含量显著低于4个洗肠组,差异有显著意义(P＜0.05)；从术后第3天开始,乳果糖组血清前白蛋白含量显著高于其他3个组,差异有显著意义(P＜0.05).结论 术前1天口服药物洗肠可缓解原发性肝癌术后血清前白蛋白下降的水平,乳果糖的作用优于硫酸镁、聚乙二醇和磷酸钠盐,对促进术后肝功能恢复有一定的作用,值得临床推广应用.
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