Cis-AT和Trans-AT聚酮合酶及其特殊功能域研究进展

摘要

Due to the diversity and specificity of polyketide synthase (PKS), the polyketide natural products generated by PKSs were structurally and bioactively diversified. Recently, the trans-AT polyketide synthase was discovered, characterized and investigated as the subfamily of Typle Ⅰ PKSs. In this review, the difference between cis-AT PKS and trans-AT PKS as wellas the research advance of special domains in trans-AT PKS were summarized and discussed. In addition, the methods could be use to modify the gene clusters to generate the novel structure compounds were also analyzed and providing the new target for natural product modification.%聚酮合酶(Polyketide synthase, PKS)是产生聚酮化合物的模块化复合酶,聚酮合酶能产生数量众多并具有生物活性的聚酮类天然产物.近年来一类与cis-AT聚酮合酶存在较大差异的trans-AT聚酮合酶被广泛研究.文章介绍cis-AT聚酮合酶与trans-AT聚酮合酶区别及trans-AT聚酮合酶基因簇中特殊功能域研究进展,展望利用功能域改造基因簇研究方向,以期为天然产物改造提供新靶点.