我院2012～2013年抗菌药物不良反应报告回顾性分析

摘要

目的：分析抗菌药物不良反应（ADR）发生的特点及临床表现，为临床合理用药提供参考。方法：对我院2012～2013年上报的124例抗菌药物ADR报告进行回顾性分析。结果：男性ADR发生率51.61%略高于女性48.39%；静脉滴注118例（95.16%）是引起ADR的主要给药途径；ADR报告中，以头孢菌素类为最多73例（58.87%），其次是氟喹诺酮类为22例（17.74%）；ADR临床表现主要为皮肤及其附件损伤为48例（38.71%），消化系统为36例（29.03%）。结论：医院应加强ADR监测工作，提高医护人员对ADR报告制度的认知，促进抗菌药物的合理应用。%Objective:This manuscript is to investigate the characteristics and clinical manifestations of the adverse drug reactions induced by antibiotic medicines in our hospital, so as to provide reference for rational clinical use of drugs. Methods:124 antibiotic medicine ADR case reports were collected from 2012 to 2013, and were analyzed retrospectively. Results: Of all antibacterial ADR cases, the incidence rate of ADR was little higher in males (51.61%) than that in females (48.39%); Intravenous route(118cases, 95.16%) was the most common route among all ADR cases, Cephalosporins (73 cases,58.87%)were the most common medicines, Fluoroquinolones(22 cases17.74%) were the second. The main clinical manifestations were skin and its appendages damage(48 cases, 38.71%), as well as gastrointestinal reaction (36 cases, 29.03%). Conclusion: More attention should be paid by hospitals to the monitoring of antibacterial ADR, enhance the doctors and nurses awareness to ADR report institutions,promote the rational use of antibacterials.