耳穴贴敷预防5-氟尿嘧啶持续化疗所致口腔炎的作用研究

摘要

Objective To explore the effect of auricular patch on the prevention of stomatitis induced by continuous fluoroura -cil chemotherapy .Methods One hundred and twenty cases of gastric cancer were recruited and randomly divided into the intervention group and the control group , each consisting of 60 patients.The two groups all received continuous fluorouracil chemotherapy , as well as traditional therapy .With the above-mentioned therapy , the patients of the intervention group had auricular patch 2 days before chem-otherapy till chemotherapy was terminated .Incidence of stomatitis in the patients of the two groups was evaluated both before and after chemotherapy.Results The incidence of stomatitis in the intervention group was 68.33%, while that for the control group was 85.00%.Furthermore, the incidences of stomatitis with Ⅱand over II degree for the intervention group and control group were 26.67%and 53.33%respectively.Total incidence and seriousness of stomatitis for the intervention group were all lower than those of the control group, and significantly statistical differences could be noted , when comparisons were made between them (P<0.05).Conclusion Auricular patch could effectively decrease the incidence of stomatitis in patients with continuous fluorouracil chemotherapy .%目的：探索耳穴贴敷在5-氟尿嘧啶持续化疗期间预防口腔炎的作用。方法选择住院胃癌患者120例，按不平衡指数最小的分配原则随机均分为干预组和对照组，每组60例。干预组和对照组均接受5-氟尿嘧啶持续化疗和其他常规治疗与护理。干预组在此基础上于化疗前2d开始进行耳穴贴敷至化疗结束。于化疗前后评价2组口腔炎的发生情况。结果干预组患者化疗后口腔炎发生率为68．3％、对照组为85．0％；而Ⅱ度以上口腔炎发生率干预组为26．7％，对照组为53．3％；干预组总发生率及口腔炎程度均低于对照组，2组比较差异有统计学意义（P＜0．05）。结论在5-氟尿嘧啶持续化疗期间，耳穴贴敷能有效降低口腔炎的发生率。