复方曲肽注射液用于防治肿瘤患者化疗后周围神经毒性的临床研究

摘要

Objective To observe the therapeutic effects of compound troxerutin and porcine cerebroside injection on the prevention and treatment of peripheral neuropathy in the patients after chemotherapy.Methods Clinical data of 58 tumor patients who received chemotherapy in the hospital from Aug.2015 to Feb.2016 were collected for the study,and the patients were randomly divided into two groups:the treatment group (n =28) and the blank control group (n =28).The treatment group received compound troxerutin and porcine cerebroside injection at a dosage of 10ml,once a day,for a succession of 3 days.Assessments of peripheral neuropathy were made by CTCAE standards and the obtained results were analyzed and compared in the patients of the 2 groups both before and after 2 cycles of chemotherapy.Results The patients all completed medical follow-ups.Before therapy,there were no statistical differences in the classification of peripheral neuropathy in the patients of the 2 groups (P ＞ 0.05).After therapy,statistical differences in the classification of peripheral neuropathy could be seen in the patients of the 2 groups(P ＞ 0.05).There were 15 patients with peripheral neuropathy before therapy.Analysis indicated that total effective rate of the treatment group was 75.00％,while that of the control treatment group was 0,and obvious statistical significance could be found when comparisons were made between the 2 groups (P ＜0.05).Conclusion Compound troxerutin and porcine cerebroside injection could produce good effect on the prevention and treatment of peripheral neuropathy induced by chemotherapy,and it was worth further clinical study by larger samples.%目的 观察复方曲肽注射液用于防治肿瘤患者化疗后周围神经毒性的疗效.方法 收集2015年8月至2016年2月在解放军总医院接受化疗的肿瘤患者的临床资料,筛选出接受具有神经毒性化疗药的患者56例,采用数字表法随机分为2组,治疗组(28例)给予复方曲肽注射液10 ml,1/d,连用3d,对照组(28例)予空白对照.分别在治疗前及2个化疗周期后对2组患者的周围神经毒性按CTCAE评价标准分级评价后进行分析和对比.结果 56例患者均完成随访,治疗前2组间周围神经毒性分级情况无统计学差异(P＞0.05);治疗后2组间周围神经毒性分级情况有统计学差异(P＜0.05);其中治疗前存在周围神经毒性的15例患者,亚组分析显示治疗组总有效率为75.00％,对照组总有效率为0,差异有统计学意义(P＜0.05).结论 复方曲肽注射液预防和治疗化疗药物引起的周围神经毒性有一定的疗效,值得临床扩大样本量进一步研究.