有毒中药的炮制解毒技术及共性解毒机制

摘要

中药炮制是一门传统的中药制药技术,通过炮制技术,药物在临床应用时可以降低毒性、增强疗效、改变药性、便于调剂制剂等.中药的炮制解毒技术是对有毒中药可以安全应用于临床的一大创举,它降低了药物的毒副作用、保证药物临床应用安全有效,并扩展药物临床应用的范围.通过对有毒中药在中医药古籍文献的记载和炮制技术整理,并对它们现代国内外前沿研究文献的归纳和分析,在毒性中药的毒性分级、毒性作用部位及毒性成分、炮制解毒技术及临床应用方面进行总结,同时提出采用相同炮制技术进行解毒的有毒中药具有共性的炮制解毒规律的理论,以期为有毒中药的炮制解毒技术及炮制解毒机制研究提供借鉴.%Chinese medicine processing is a kind of traditional pharmaceutical technology,which can reduce toxicity,enhance the curative effect,change the properties and facilitate dispensing preparations in clinical use.The technology of detoxification is a great pioneering work for the safe application of toxic Chinese medicine,which can reduce the side effects of certain drugs,ensure the clinical safe use and expand the scope of clinical application through processing.In this paper,we searched the toxic Chinese medicine and the processing technology in ancient literatures of TCM,and then we summarized and analyzed their lat-est studies at home and abroad.Thus,we make a summary of toxic Chinese medicine including its classification,site of action,the toxic components,detoxification and its clinical application.Meanwhile,we proposed an opinion that toxic Chinese medi-cines with the same processing technology had common detoxification rules.Therefore,we hope this work will provide new perspectives for the research on the processing of toxic Chinese medicine and the mechanism of detoxification.