出血性脑卒中患者血管内皮祖细胞与相关危险因素的关系

摘要

目的 探讨血管内皮祖细胞(endothelial progenitor cells,EPCs)与出血性脑卒中危险因素的关系及临床意义.方法 对75例不同时期的原发性脑出血卒中患者(急性期38例、稳定期37例)进行危险因素分析,以CD133/KDR+作为EPCs标记物,用流式细胞仪检测患者的CD133/KDR+双标记细胞数量,并与40例健康对照组循环EPCs水平进行比较.结果 外周循环EPCs数量与高血压、高血糖、高血脂呈负相关(P＜0.05或P＜0.01);高血压、高血糖、高血脂、吸烟、饮酒能影响患者循环EPCs的水平(均P＜0.05),而脑卒中家族史对循环EPCs水平无明显影响(P＞0.05).脑出血卒中患者循环EPCs水平明显低于对照组(P＜0.05).结论 循环EPCs水平与脑出血危险因素负相关,可作为出血性脑卒中患者脑血管危险度的标志.%Objective To investigate the relationship between endothelial progenitors cells (EPCs) and risk factors for primary intracerebral haemorrhage.Methods Seventy-five patients with primary intracerebral hemorrhage (38 patients with acute,37 patients with stable)were enrolled to assess the risk factors.The number of circulating EPCs in these patients was measured as CD133/KDR+ double positive cells using flow cytometry and was compared with that in 40 healthy controls.Results The number of circulating EPCs was inversely correlated with hypertension,hyperglycemia and hyperlipemia (P＜0.05 or P＜0.01).No significant correlation existed between the history of stroke and levels of circulating EPCs(P＜0.05).Hypertension,hyperglycemia,hyperlipidemia,smoking,drinking can affect the level of patients with circulating EPCs (all P＜0.05).The levels of EPCs in patients with intracerebral hemorrhage were significantly lower than those in healthy controls(P＜0.05).Conclusion The levels of circulating EPCs were negatively correlated with risk factors for intracerebral hemorrhage, and can be considered as a predictor of cerebrovascular risk in patients with primary intracerebral hemorrhage.