乙型肝炎病毒HBx的分子生物学研究进展

摘要

HBx is a hepatitis B virus genome encoded protein composed of 154 amino acids.It posesses a variety of biological activities,involving in replication and transcription of HBV ge-nome,transcription of host cell genes,signal transduction,cell cycle regulation and apoptosis.HBx plays a critical role in the replication and infection of HBV,pathogenesis of liver diseases and hep-atocarcinoma.%HBx是乙型肝炎病毒基因组编码的154个氨基酸组成的多肽蛋白，具有多种生物学活性，参与 HBV基因组的复制转录、宿主细胞基因转录、信号转导、细胞周期调控和细胞凋亡等调节，在 HBV复制感染、致肝病及肝癌的分子机制中起着关键作用。