控制尿酸与短期内心房颤动复发相关性的研究

摘要

Objective To investigate the correlation between acid-lowering therapy and short-term atrial fibrillation recurrence.Methods According to the diagnostic criteria for atrial fibrilla-tion and hyperuricemia,actual use of uric acid-lowering drugs and recurrence of atrial fibrillation within 6 months,data of 126 patients with atrial fibrillation who underwent successful cardiover-sion were analyzed retrospectively.The rates of uric acid control and atrial fibrillation recurrence were calculated to investigate the role of acid-lowering therapy in the prevention of atrial fibrilla-tion recurrence.Results Compared with control group,the decrease rate of uric acid significantly increased and the recurrence rate of atrial fibrillation obviously decreased in study group(88.9%vs 3.7% and 19.4% vs 68.5%,respectively;P <0.05).Conclusion Acid-lowering therapy can effectively prevent short-term atrial fibrillation recurrence.%目的 探讨降低尿酸治疗与预防短期内心房颤动复发的相关性.方法 根据心房颤动及高尿酸血症的诊断标准,结合确诊患者的降尿酸药物治疗实际使用情况,回顾性分析126例经复律成功的心房颤动住院患者出院后是否进行降低尿酸治疗及其半年内心房颤动的复发情况,根据统计学方法分析计算出研究组(进行降低尿酸治疗)及对照组(未进行降低尿酸治疗)各自的尿酸控制率、心房颤动复发率等相关指标,从而探索降低尿酸处理对于预防心房颤动复发的作用及意义.结果 研究组尿酸的控制率及达标率明显高于对照组(研究组患者尿酸有效降低百分占比为88.9%,而对照组仅为3.7%);研究组经降低尿酸处理后半年内心房颤动的复发率为19.4%,而同期比较对照组患者半年内心房颤动的复发率为68.5%;研究组患者在经过降低尿酸处理后半年内心房颤动的复发率与对照组比较,差异具有统计学意义(P<0.05).结论 降低尿酸治疗对于短期内预防心房颤动的复发具有积极意义,可以有效起到预防心房颤动复发的作用.