Xp11.2易位/TFE3基因融合相关性肾癌与肾透明细胞癌的螺旋CT诊断鉴别

摘要

Objective To evaluate the significance of spiral CT scan in diagnosis and differential diagnosis of renal carcinoma associated with Xpll. 2 translocation/TFE3 gene fusions and clear cell renal cell carcinoma. Methods We retrospectively analyzed the spiral CT data of 24 cases proved to be Xpll. 2 translocation renal carcinoma and clear cell renal cell carcinoma by surgery and pathology. There were 12 cases respectively in the Xpll. 2 translocation renal carcinoma group and clear cell renal cell carcinoma group. Results The average enhanced CT value of the Xpll. 2 translocation renal carcinoma and clear cell renal cell carcinoma was (31. 75+14. 73)Hu and(88. 30 + 31. 91)Hu respectively, showing significant difference (P< 0. 01). Conclusion Observing the CT value of the lesions may help to determine the prcopcrativc pathological subtype of the tumor preliminarily.%目的 评价螺旋CT 扫描在Xp11.2易位/TFE3基因融合相关性肾癌和肾透明细胞癌的诊断和鉴别诊断中的应用价值.方法 回顾性分析经手术病理证实为Xp11.2易位/TFE3基因融合相关性肾癌和肾透明细胞癌的24例患者的螺旋CT资料.其中Xp11.2易位/TFE3基因融合相关性肾癌和肾透明细胞癌各12例.结果 Xp11.2易位/TFE3基因融合相关性肾癌组和肾透明细胞癌组的平均CT值增强量(即增强扫描动脉相肿瘤最大横截面平均CT值-平扫相上肿瘤最大横截面平均CT 值)分别为(31.75±14.73)Hu和(88.30±31.91)Hu,Xp11.2易位/TFE3基因融合性肾癌的CT增强幅度明显小于肾透明细胞癌(P＜0.01).结论 观察病灶的CT值,可以帮助医师初步确定术前肿瘤的病理亚型.