一次性按需口服西地那非对特发性少弱精子症精液参数的影响

摘要

Objective To evaluate the effects of acute administration sildenafil on the seminal parameters in idiopathic oligoasthenozoospermia patients.Methods A total of 216 patients with idiopathic oligoasthenozoospermia were collected for prospective,dynamic balanced randomized clinical trails on semen parameters during March 2015 and June 2016.During the first visit,after medical history was collected and physical examination was conducted,the routine parameters of semen were detected.In the subsequent visit,30 min after the administration of a single dose of sildenafil (50 mg),the semen samples were collected.Changes in sperm parameters were analyzed and the side-effects were recorded.Results A significant increase in sperm progressive motility [(7.4±6.7) ％ vs.(15.7±8.7)％,P＜0.05] and total number of progressive sperm [(8.4±7.6))× 106 vs.(12.2 ± 9.1) × 106,P ＜ 0.05] were observed after sildenafil administration as compared with baseline.No serious side-effects occurred.Conclusion These preliminary results indicate that progressive sperm motility and total number of progressive sperm appear to be promoted in idiopathic oligoasthenozoospermia patients after the acute administration of a single dose of sildenafil.%目的 探讨一次性按需口服西地那非对特发性少弱精子症精液参数的影响.方法 2015年3月至2016年6月上海交通大学附属第一人民医院男科门诊采用动态均衡随机化方法收集特发性少弱精子症患者216例.初诊时经病史采集、体检后,按照WHO5行精液常规参数检测及相关检查,复诊时精液采集前0.5h给予西地那非50 mg单次口服(禁欲3～5 d),复查精液参数,观察精液参数变化,并问询服药过程中的不良反应.结果 一次性按需口服西地那非前后精液体积、精浆生化、精子浓度、精子形态学无明显差异;用药后,前向运动精子百分比[(15.7±8.7) vs.(7.4±6.7)％,P＜0.05]、前向精子运动总数[(12.2±9.1)×106 vs.(8.4±7.6)×106,P＜o.o5]明显改善.口服西地那非治疗期间,患者未出现明显严重不良反应.结论 一次性按需口服西地那非可增加前向运动精子总数,改善部分少弱精子症患者精液参数.