Objective To observe antimicrobial activity of four types of root canal sealers. These sealers are divided into four groups. Nano-zinc-oxide sealer (N-ZO); nanohydroxyapatite sealer (NHA); AH Plus and mineral trioxide aggregate (MTA). Methods Agar diffusion test. We selected Staphylococcus aureus, Candida albicans, E. faecalis and E. coli as experimental strains. We put these strains in an incubator at 37℃. After 24 hours, we observed the diameter of bacteriostatic circle. Results Antimicrobial activity is found in AH plus and N-ZO, while neither MTA nor NHA presents such activity. N-ZO indicated the largest inhibition zone (8 to 18 mm). E. faecalis showed resistance to all experimental materials. Conclusion N-ZO and AH Plus have higher antimicrobial activity, while MTA and NHA have no such activity, and all experimental materials fail to inhibit E. faecalis.%目的 观察四种根管封闭剂的抗微生物作用:纳米氧化锌糊剂(N-ZO),纳米羟磷灰石糊剂(NHA),AH Plus,mineral trioxide aggregate( MTA).方法 采用琼脂扩散法,选择金黄色葡萄球菌、白色念珠茵、粪肠球菌、大肠杆菌作为实验菌种.观察37℃培养24小时的抑菌环直径.结果 MTA和NHA均没有显示出抑茵作用,只有AH Plus与N -ZO组对金黄色葡萄球菌、白色念珠菌、大肠杆菌有抑茵作用.其中N-ZO产生了最大的抑茵范围从8mm至18mm,粪肠球菌对所有的实验材料都抵抗.结论 纳米氧化锌糊刑和AH Plus具有较强的抗微生物作用,而MTA和纳米羟磷灰石糊剂无抑茵作用.所有实验材料对粪肠球菌都没有抑茵作用.
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