微波凝固术后肝癌患者免疫功能变化的初步研究

摘要

Objective :To study the influence of percutaneous microwave coagulation therapy ( PMCT ) on immunity function of patient with hepatocellular carcinoma( HCC ). Methods : Sixty eight HCC patients were treated by PMCT, the changes of CD4 + , CD8 + ,CD4 +/CD8 + , NK cell by cytomatric analysis of peripheral blood were observed at day 1 before PMCT, daym 7 day 14 , day 21 and 28 after PMCT. Results : At day 7 , CD4 + , CD8 + , CD4 + /CD8 + , NK cell did not changed;CD4 + increased obviously at day 14 after PMCT, while CD8 + decreased obviously. NK cell level was increased at week 4 after PMCT. Conclusion : The immune function of patient was significantly improved in short - term after PMCT. And it played important role to prognosis of patient with liver cancer.%目的:检测微波凝固术后肝细胞肝癌患者外周血免疫细胞指标,探讨微波凝固治疗对患者机体免疫功能的影响.方法:68例行肝癌微波凝固术治疗的患者,分别于微波凝固治疗前1天、治疗后7天、14天、21天和28天时,应用流式细胞技术检查患者外周血CD4+、CD8+、CD3+、CD4+/CD8+比值、NK细胞水平的变化.结果:微波凝固后第1周,各指标较术前无明显变化,第2周开始,CD4+值比术前明显上升,CD8+明显下降,第4周开始NK细胞水平明显升高.结论:微波凝固治疗后肝癌患者免疫功能增强,将对肝癌患者的预后起到重要作用.