抑癌基因ARHI与全身各系统肿瘤相关性及机制的研究进展

摘要

抑癌基因 ARHI（aplasia ras homologue I）是1999年新发现的母源性印迹基因。最近研究发现ARHI 具有抑制肿瘤细胞增殖、转移、侵袭，调控肿瘤细胞自噬等作用。另外，学者们还发现 ARHI 不仅与卵巢癌、乳腺癌、胰腺癌密切相关，而且还与其他生殖、消化、内分泌等全身各系统肿瘤具有相关性。本文就最近几年国内外对 ARHI 与全身各系统肿瘤的相关性及其机制的最新研究进展进行综述。%The tumor suppressor gene ARHI(aplasia ras homologue I),is a new - found maternal imprinted gene in 1999. Recent studies have found ARHI inhibit tumor cellsˊ proliferation,metastasis,invasion,regulation of tumor cell autophagy and so on. In addition,the researchers also found that ARHI is not only closely related with ovarian cancer, breast cancer,pancreatic cancer,but also relevant with other reproductive,digestive,endocrine systemic tumors of the body. This review progresses the latest researches of the relationship and mechanisms of the ARHI and the systemic tumors of recent years,and expand to provide reference for clinical diagnosis and treatment of cancer.