目的：通过幽门结扎性胃溃疡模型、醋酸性胃溃疡模型及乙醇致胃溃疡模型研究山橿提取物对溃疡面积的影响。方法选取中南大学湘雅医学院实验动物中心提供的清洁级SD大鼠50只，按随机数字表法分为五组：模型组（等体积蒸馏水）、奥美拉唑组（0.018 g/kg）和山橿提取物组（低、中、高剂量组，1.500、3.500、7.000 g/kg），每组10只，进行相应处理后，比较分析不同剂量山橿提取物对胃溃疡大鼠模型的影响。结果与模型组比较，山橿提取物中、高剂量组均能显著减少胃溃疡面积，其抑制率分别为35.20%和52.94%，且呈良好量效关系，差异均有统计学意义（P<0.01或P<0.05）。结论山橿提取物对大鼠胃溃疡有治疗作用，应对其治疗作用进行更深入的研究。%Objective To study the influence of extracts from Lindera reflexa Hemsl on the rat ulcer area by the pylorus ligation stomach ulcer model,acetic acid caused stomach ulcer model and ethanol caused stomach ulcer model. Methods Fifty clean grade SD rats provided by the experimental animal center of Xiangya Medical College of Central South University were se lected and randomly divided into 5 groups according to the random number table method:model group(isovolemic distilled water ) , omeprazole group(0.018 g/kg) and Lindera reflexa Hemsl extract group(low,middle and high dose groups,1.500,3.500,7.000 g/kg), 10 rats in each group. After the corresponding treatment ,the influences of different Lindera reflexa Hemsl extract on the stomach ulcer rat model were compared among the different doses. Results Compared with model group,the middle and high Lindera re-flexa Hemsl extract dose groups could significantly reduce the stomach ulcer area ,their inhibition rate on stomach ulcer were 35.20%and 52.94% respectively,moreover which showed a good does dependent manner,the differences were statistically sig nificant(P<0.05). Conclusion The Lindera reflexa Hemsl extract has a treatment effect on stomach ulcer in rats. So the research on its curative effect should be more deeply conducted.
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