产I型新德里金属β-内酰胺酶耐药菌的研究概况及应对措施

摘要

The New Delhi Metallo-β-lactamase 1 (NDM 1) has been initially identified in multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates in 2008. Today it could be found in India ,UK ,USA ,Canada ,the Netherlands ,Australia and China. There was one case of NDM-1 positive bacteria at least which was resistant to all known antibiotics so far. This paper briefly discussed the discovery ,development,drug resistance, genetic character of NDM 1 bacteria and the corresponding strategies to precaution and control the NDM-1 positive bacteria.%2008年首次在大肠埃希菌和肺炎克雷伯菌中确认了Ⅰ型新德里金属β-内酰胺酶(New Delhi Metalloβ-lactamase 1,NDM-1).目前产NDM-1酶细菌在印度、英国、美国、加拿大、荷兰、澳大利亚以及中国等国均有报道.研究发现至少一例NDM-1阳性菌对所有已知的抗生素具有耐药性.该文简要介绍了NDM-1耐药菌的发现、发展过程及其耐药性情况,基因特点以及NDM-1阳性菌的应对措施.