网织血小板检测在妊高征患者中的临床意义

摘要

目的 探讨网织血小板在妊娠高血压综合征(简称妊高征)患者中的变化及临床意义.方法 对经临床确诊的108例妊高征患者、40例正常晚期妊娠妇女与40例正常非孕妇女进行网织血小板百分率(IPF%)、血小板计数(PLT)、平均血小板体积(MPV)及血小板分布宽度(PDW)的检测,并进行统计学分析.结果 妊高征组的IPF%较正常非孕对照组及正常晚期妊娠组明显升高,与正常非孕对照组比较差异有统计学意义(t=3.94,P<0.001),与正常晚期妊娠组比较差异有统计学意义(t=3.30,P=0.001).妊高征组的PLT较正常非孕对照组及正常晚期妊娠组降低,与正常非孕对照组比较差异有统计学意义(t= 2.02,P=0.042),而与正常晚期妊娠组比较差异无统计学意义(t=0.30,P=0.785).妊高征组的MPV较正常非孕对照组及正常晚期妊娠组升高,与正常非孕对照组比较差异有统计学意义(t=3.73,P<0.001),而与正常晚期妊娠组比较差异无统计学意义(t=1.41,P=0.146).妊高征组的PDW较正常非孕对照组及正常晚期妊娠组明显升高,与正常非孕对照组比较差异有统计学意义(t=4.28,P<0.001),与正常晚期妊娠组比较差异有统计学意义(t=3.38,P=0.001).结论 网织血小板检测能够更准确地反映骨髓中血小板的生成情况,对监测妊高征病情发展及预测预后有一定的临床价值.%Objective To investigate the change of the reticulated platelet in pregnancy induced hypertension (PIH). Methodsrn108 PIH women,40 normal late pregnant women and 40 normal un pregnant women were studied. IPF% ,PLT,MPV and PDW were measured. Results IPF% and PDW were higher in PIH women than those in normal un pregnant women (t= 3.94,P<0. 001; t=4 28, P<0. 001) and normal late pregnant women (t=3. 30 , P=0. 001; t= 3. 38, P= 0. 001). PLT was lower in PIH women than those in normal un pregnant women (t= 2. 02, P= 0. 042) , but there was no significant difference compared to normal late pregnant women (t=0. 30, P= 0. 785). MPV was higher in PIH women than those in normal un pregnant women (t=3. 73,P<0. 001) ,but there was no significant difference compared to normal late pregnant women (t= 1. 41,P=0. 146). Conclusion The detection of reticulated platelet couldreveal platelet production in bone marrow, which have a certain clinical value on the development and prognosis of PIH.