长链非编码RNA及其在肾癌中的研究进展

摘要

长链非编码RNA(long non-coding RNA,lncRNA)是一类长度大于200个核苷酸的不编码蛋白质的RNA,长期以来,lncRNA被当作基因组的"垃圾序列".然而,近年来,越来越多的研究表明lncRNA广泛地参与了细胞生物学全过程,有多种多样的生物学功能.LncRNA与许多疾病尤其是肿瘤密切相关,近年来,肾癌中也有一大批lncRNA分子逐渐被阐明.本文主要对lncRNA分类和功能,以及lncRNA在肾癌中的研究进展作综述.%Long non-coding RNA(lncRNA)is a kind of RNA which possess longer than 200 nucleotides and lack of protein coding function.It was recognized as junk sequence for a long time.Recent studies have found that lncRNAs were actively function in almost every aspect of cell biology, and involved in a variety of biological functions.LncRNAs were closely related to a variety of human diseases, especially tumors.Recently, lncRNAs were being increasingly reported in Renal Cancer.Following is a review of the classification and functions of lncRNAs, and also the latest research progresses of lncRNAs in renal cancer.