白假丝酵母与细菌相互作用机制及其与感染的关系

摘要

Microbial communities with complex structure are colonized in human body,hosting interactions between fungi and bacteria.Early studies have focused mainly on a single species of bacteria or fungi,and recent studies have shown the interactions between bacteria and fungi are critical to study human microecosystems.Candida albicans is the most common opportunistic pathogenic fungus for human and is generally considered to be part of the normal human flora.The interactions between Candida albicans and bacteria,especially their synergistic and antagonistic effects on the balance between different species,have attracted more attentions in recent years.This paper reviews the mechanism of interactions between Candida albicans and bacteria and their impacts on human diseases.%人体内定植着数目庞大、结构复杂的细菌及真菌等微生物群,它们之间存在复杂的相互作用.既往研究主要集中于细菌或真菌的某个单一物种,但最近研究表明,细菌与真菌之间的相互作用对更好地理解体内的微生态系统至关重要.白假丝酵母(又称白念珠菌)是人备体中最常见的机会性致病真菌,通常被认为是人类正常菌群的一部分.白念珠菌与细菌的相互作用近年来备受关注,其协同和拮抗作用有助于维持不同物种间复杂的平衡关系.了解白念珠菌与细菌的相互作用,不仅可加深对微生物致病机制的理解,还可为预防和治疗白念珠菌或细菌感染及新型抗菌药物研发提供新途径.本文就白念珠菌与细菌共存时的相互作用机制及其对人类健康、疾病的影响进行综述,从而为控制念珠菌或细菌感染提供新的策略.