活血化淤法辅助治疗严重脓毒症的临床研究

摘要

目的：研究活血化淤法辅助治疗严重脓毒症患者的临床疗效。方法：将60例符合纳入标准的严重脓毒症患者随机分为2组，治疗组30例采用西药常规疗法联合口服活血化淤汤剂治疗，对照组30例采用西药常规疗法治疗，疗程14d。比较2组治疗前、后中医证候疗效、APACHEⅡ评分、Marshall器官功能障碍评分的变化情况，比较2组病死率的差异。结果：治疗组中医证候疗效明显优于对照组（P＜0．05）；治疗后2组APACHEⅡ评分、Marshall器官功能障碍评分均较治疗前降低（P＜0．05），且治疗组APACHEⅡ评分及Marshall器官功能障碍评分降低幅度高于对照组（ P＜0．05）；治疗组28d病死率低于对照组。结论：活血化淤法辅助治疗严重脓毒症患者可更有效的改善患者临床症状，降低APACHEⅡ评分及Marshall器官功能障碍评分，降低病死率。%Objective :Observing the effectiveness of promoting blood circulation to remove blood stasis as adjuvant therapy in patients with severe sepsis .Methods :60 patients with severe sepsis meeting the inclusion criteria were ran-domly divided into two groups .In the treatment group ,30 cases were treated with routine therapy combined with oral blood circulation decoction treatment .30 cases in the control group were employed conventional western medicine thera-py .Both period of treatment was 14d .Some outcomes were compared before and after treatment of TCM syndrome in-cluding APACHE Ⅱ score ,Marshall organ dysfunction score changes and differences in mortality between the two groups .Results:TCM syndrome scores in the treatment group is apparently more than those in the control group (P<0 .05);after treatment APACHE Ⅱ score ,Marshall organ dysfunction score decreased in both of the groups (P<0.05) ,but there is significant difference between the two groups in this two indexes (P<0 .05) ,at last the mortality of the treatment group is lower than that of the control group after 28 days .Conclusion:Promoting blood circulation to re-move blood stasis as adjuvant therapy in patients with severe sepsis can improve the syndromes and lower APACHE Ⅱscore ,Marshall organ dysfunction score and mortality .