早期胰岛素强化治疗对急性重症胰腺炎患者炎症因子及预后的影响

摘要

Objective :To explore the effect of early intensive insulin therapy on inflammatory factors and prognosis of severe acute pancreatitis patients .Methods :Selected 68 cases of severe acute pancreatitis patients in our hospital from June 2012 to September 2014 for sampling ,were randomly divided into two groups ,the control group received routine treatment ,the experimental group implementation of early intensive insulin therapy ,compared serum levels of inflam‐matory mediators of two groups to improve the condition and prognosis .Results:(1) Compared to TNF‐α,CRP ,IL‐8 level :1d after treatment ,the levels of CRP and TNF‐αof experimental group were significantly lower than that of con‐trol group (P<0 .05);after treatment 3d and 7d ,the level of CRP ,IL‐8 and TNF‐αin experimental group were lower than control group (P< 0 .05);(2) prognosis :hospitalization time in experimental group was shorter than control group (P<0 .05) ,after 72h treatment APACCHE Ⅱ score was lower than control group (P<0 .05) .Conclusion:The clinical effect of early intensive insulin therapy on patients with severe acute pancreatitis is definite ,can regulate the body high inflammatory state in patients ,improve prognosis ,clinical attention should be paid .%目的：探究早期胰岛素强化治疗对急性重症胰腺炎患者炎症因子及预后的影响。方法：择取我院2012年6月－2014年9月收治的急性重症胰腺炎患者进行抽样，选取68例患者随机分成两组，对照组实施常规治疗，实验组实施早期胰岛素强化治疗，对比两组血清炎症介质水平改善情况及预后状况。结果：（1）TNF‐α、CRP、IL‐8水平比较：于治疗后1d ，实验组CRP、TNF‐α水平明显均低于对照组（P＜0．05）；于治疗后3、7d ，实验组CRP、IL‐8及 TNF‐α水平均低于对照组（P＜0．05）；（2）预后比较：实验组住院时间明显短于对照组（P＜0．05），治疗72h后APACCHEⅡ评分低于对照组（P＜0．05）。结论：早期胰岛素强化治疗急性重症胰腺炎患者临床疗效确切，可调节患者体内高炎症状态，改善其预后，临床上应引起足够重视。