陈兰花冲剂对糖尿病足大鼠血清TNF-α、IL-6、CRP的影响

摘要

目的 研究陈兰花冲剂对糖尿病足大鼠炎性因子的影响.方法 采用腹腔注射STZ,足部注射真菌菌液方法复制大鼠糖尿病足模型.采用ELISA法、液相免疫沉淀散射比浊终点法观察陈兰花冲剂对大鼠血清炎性因子的影响.结果 陈兰花冲剂可降低大鼠血清CRP、IL-6、TNF-α炎性因子的水平.结论 本实验初步证明了糖尿病足的炎症发生机制以及陈兰花冲剂的抗炎作用.%Objective To study the effect of Chenlanhua chongji on inflammatory cytokincs of diabetic foot rat Methods Diabetic rat models were established by abdomen injection of STZ, then fungi were injected into rat digits and diabetic foot models were copied.The effect of Chenlanhua chongji on rat serum inflammatory cytokines level was observed by the method of ELISA.Results CRP,IL - 6 , TNF - α were degraded by Chenlanhua chongji.Conclusion This experiment tested the inflammatory mechanism of diabetic foot and the effect of Chenlanhua chongji on restraining inflammation.