肝细胞癌组织中HLA-DR,-DQ的表达及其意义

摘要

Objective To study the expression of HLA - DR and HLA - DQ antigens in hepatocellular carcinoma ( HCC ) and its significance. Methods The expression of HLA - DR and HLA - DQ antigens in human 38 HCCs cases were detected with immunohistochemistry, then the relations between the expression of genes with clinical and pathology parameters ( such as cancerous differentiation and metastasis and others) were analyzed by Chi square test. Results The immunoreactivity of HLA - DR and - DQ proteins were mainly distributed in cytoplasm of cancerous cells, the positive rate of HLA - DR and DQ expression were 5. 3％ (2/35 ) and 92. 1％ ( 35/38) respectively. HLA - DR was related with gender of HCC patients, HLA - DQ was positive relation with non - lymphatic metastasis of HCC (P ＜0.0001 ). Conclusion HLA - DQ expression is very common in HCCs; The absence of HLA - DQ expression may contribute to lymphnodes metastasis in HCC.%目的 探讨人白细胞抗原(HLA)-DR和-DQ分子在肝细胞癌的表达及其意义.方法 采用免疫组化法分别检测HLA-DR和HLA-DQ抗原在38例人肝癌组织芯片中的表达情况,并和临床病理资料进行相关性分析.结果 肝癌组织中HLA-DR和HLA-DQ抗原信号主要定位于细胞浆.HLA-DR的阳性率为5.3%(2/38),HLA-DQ的阳性率为92.1%(35/38),但在4例伴淋巴结转移的肝癌中,3例无HLA-DQ的表达,HLA-DQ表达与肝癌的淋巴结转移负相关(P＜0.0001).HLA-DR和HLA-DQ表达与年龄和肝癌的组织分化无相关性(P＞0.05).结论 HLA-DQ的表达在肝癌组织中很常见,无HLA-DQ的表达可能提示与淋巴结转移有关.