To evaluate the therapeutic and prophylatic effect of bicyclol on drug - induced liver injury for lung cancer patients. Methods Totally 153 non - small cell lung cancer patients with hepatic injury were randomly divided into two groups; treatment group with 77 cases who received bicyclol 150mg/d orally and the control group with 76 cases who received diammonium glyeyrrhizinate capsule 150mg/d. After the recovery of hepatic function, they started another two chemotherapy cycles in combination with liver - protective agents respectively and wecompared the changes of hepatic function between two groups. Results After treatment, the hepatic functions of patients in two groups ail improved, but the treatment group is more significant (P<0.05, P <0.01). Prophylatic administrated with bicyclol showed a lower degree of hepatic injury to Diammonium Clycyrrhizinate (P<0.01) and the rates of hepatotoxicity with I-? degree of treatment group was significantly lower than the control group ( P < 0.05). Conclusion Bicyclol 150mg/d is effective in the treatment and prevention of lung cancer chemotherapy induced iiver injury.%目的 评价双环醇片对肺癌患者药物性肝损伤的治疗及预防作用.方法 153例非小细胞肺癌化疗药物性肝损伤的患者随机分为两组:治疗组77例,口服双环醇片150mg/d(每次50mg,每天3次),对照组76例,口服甘草酸二铵胶囊450mg/d(每次150mg,每天3次).经治疗肝功能恢复正常后再按照原方案和剂量化疗,同时两组各自继续口服保肝药物对肝损伤进行预防.再完成2个周期化疗.比较两组治疗及预防后对肝功能的影响.结果 治疗后,两组肝功能均有改善,但治疗组更为明显(P＜0.05,P＜0.01),预防处理后,按原方案继续化疗两个周期后,预防性并用双环醇片组肝功能损害程度明显低于对照组(P＜0.01),双环醇组出现肝功能Ⅰ～Ⅳ度损害的发生率明显低于对照组(P＜0.05).结论 双环醇片150mg/d可有效治疗和预防肺癌化疗药物导致的肝损伤.
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