肺功能及血清炎性因子与老年高血压合并冠状动脉疾病的关系

摘要

目的 探讨肺功能及血清炎性因子与老年高血压合并冠状动脉疾病的关系.方法 选择152例患高血压疾病的患者,根据是否合并冠状动脉疾病,将患者分为合并冠状动脉疾病组和非合并冠状动脉疾病组,合并冠状动脉疾病组84例,非合并冠状动脉疾病组68例.结果 对比两组的一般资料,发现高血压合并冠状动脉疾病组患者与非合并冠状动脉疾病组患者的年龄(75.23 ±7.49岁vs 71.42±8.21岁)、甘油三酯(1.59±0.41mmol/L vs 1.41±0.63mmol/L)、血肌酐(82.42±39.27μmol/Lvs 70.39±25.76μmol/L)、血尿素氮(7.85±4.31mmol/L vs 6.12±2.49mmol/L)、IL-2(567.32pg/dl±191.53pg/dl vs 501.26±217.74)、IL-6(3.95±2.92pg/dl vs 3.04±2.61pg/dl)和CRP(1.75±1.84mg/dl vs 1.04±2.01mg/dl)相比较高,而FEV1％(83.42％±24.57％ vs92.15％±19.38％)和FEV1/FVC(62.91±13.65 vs 70.24±9.42)更低,差异均有统计学意义(P＜0.05);对差异有统计学意义的相关因素进行线性回归分析发现,FEV1％ (P =0.005)、FEV1/FVC(P =0.003)、IL-2(P=0.012)和CRP(P =0.009)差异更明显,为高血压合并冠状动脉疾病的独立相关因素;对高血压患者的血清炎性因子IL-2、CRP与肺功能指标FEV1％和FEV1/FVC进行相关性分析发现,血清炎性因子IL-2与肺功能指标FEV1％(r=-0.391,P=0.000)和FEV1/FVC(r=-0.571,P=0.000)呈负相关,CRP也与肺功能指标FEV1％(r=-0.437,P=0.000)和FEV1/FVC(r=-0.559,P=0.000)呈负相关.结论 肺功能及血清炎性因子是老年高血压合并冠状动脉疾病的危险因素.%Objective To investigate the relationship between pulmonary function,serum inflammatory factors and coronary artery disease in elderly patients with hypertension.Metbods One hundred and fifty-two patients with hypertensive disease were involved.According to whether the patients had coronary artery disease,the patients were divided into hypertension with coronary artery disease group included 84 patients and non-combined coronary artery disease group included 68 patients.Results Age (75.23-± 7.49years vs 71.42 ± 8.21years),triglyceride (1.59 ± 0.41mmol/L vs 1.41 ± 0.63mmol/L) serum creatinine (82.42 ± 39.27μmol/L vs 70.39 ±25.76μmol/L),blood urea nitrogen (7.85 ± 4.31mmol/L vs 6.12 ± 2.49mmol/L),IL-2 (567.32 ± 191.53pg/d1 vs 501.26 ±214.74pg/dl),IL-6 (3.95 ± 2.92pg/dl vs 3.04 ± 2.61pg/dl) and CRP (1.75 ± 1.84mg/dl vs 1.04 ± 2.01 mg/dl) of hypertension with coronary artery disease group were higher than hypertension non-combined coronary artery disease group,however FEV1％ (83.42％ ± 24.57％ vs 92.15％ ± 19.38％) and FEV1/FVC (62.91 ± 13.65 vs 70.24 ± 9.42) were more lower.There was significant difference (P ＜ 0.05).From the multiple linear regression analysis of relevant factors,we found that FEV1 ％ (P =0.005),FEV1/FVC (P =0.003),IL-2 (P =0.012) and CRP (P =0.009) was independently associated with hypertension complicated with coronary artery disease.From the analysis between IL-2,CRP and FEV1％,FEV1/FVC of hypertensive patients with coronary artery disease,we found that IL-2 was significantly negatively correlated with FEV1 ％ (r =-0.391,P =0.000) and FEV1/FVC (r =-0.571,P =0.000),and CRP was also was significantly negatively correlated with FEV1％ (r =-0.437,P =0.000) and FEV1/FVC (r =-0.559,P =0.000).Conclusion We find that pulmonary function and serum inflammatory factors are the risk factors of the coronary artery disease in elderly patients with hypertension.