TLR9与先天性免疫反应

摘要

TLR9 ( Toll-like receptor 9 ) is one of the microbial pathogen-associated molecular pattern ( PAMP ) receptors. TLR9 recognizes stimulatory CpG-ODN and allows pathogen recognition receptors ( PRRs ) to present on innate immune cells and become activated. TLR9 plays an important role in innate immune system, such as sepsis, inflammatory foam cell formation, autoimmune disease, concanavalin A-induced hepatitis and ischemia reperfusion injury ( IRI ). TLR9 is also considered to be association with other etiological factors, for example, liver X receptor, formylpeptide receptors ( FPRs ) and mitochondria DNA.%TLR9(Toll-like receptor 9)是一种微生物病原相关分子结构模式识别受体,TLR9能够识别CpG-ODN(胞嘧啶磷酸鸟甘-寡聚脱氧核苷酸),使病原相关受体在先天性免疫细胞上表达,并激活下游炎性通路.研究表明,TLR9在先天性免疫反应中产生了重要作用,如脓毒血症、自身免疫性疾病、刀豆体球蛋白A介导肝炎性肝脏损伤、炎性泡沫细胞形成、缺血再灌注损伤等,并且与多种致病因子相关联,如肝X受体、甲酰多肽受体、线粒体DNA等.