18F-FDG和18F-FLTPET/CT在肺部良恶性肿瘤鉴别诊断中的价值

摘要

Objective:The study aims were to investigate the diagnostic performance of dual-tracer ( 18F- fluorodexyglucose [18F-FDG] and 18F-fluorothymidine [18F-FLT] PET/CT in pulmonary nodules, to differentiate the malignant tissue from benign pulmonary nodules. Methods:Fifty-five patients were chose in our study, in which 28 had one pulmonary nodule only, others had more than two pulmonary nodules, with the diameter of pulmonary nodule from 0. 6 to 11. 0 centimeters. All the patients underwent 18F-FDG and 18F-FLT PET/CT and the maximal standardized uptaken value (SUV) of 18F-FDG or 18F-FLT were determined. PET/CT resultes were correlated with age. Diameter of the nodule, and histopathologic types. Results: There were no significant differences between the SUV of 18F-FDG and age. Diameter of the nodule, type of the pathologic nature of nodule of all fifty-five patients ( P >0. 05). Otherwise, there were significant differences between the SUV of 18F-FLT and the type of pathologic nature of nodules of all fifty-five patients (P <0. 05), Conclusion: The study shows that 18F-FLT PET/CT SUV can accurately differentiate segments with carcinoma from benign nodules.%目的:分析18F-FDG(18F-脱氧葡萄糖)和18F-FLT(18F-胸腺嘧啶)两种显像剂的PET/CT检查在肺部肿瘤中的不同影像学表现,提高PET/CT在肺部良恶性肿瘤鉴别诊断中价值,从而为临床治疗方案的选择提供可靠依据.方法:收集肺肿瘤患者55例为研究对象,其中男性33例,女性22例,年龄17～82岁,28例为肺内孤立肿块,其余为2～3个肿块,肿块大小0.6～11.0cm,所有患者均行肺部18F-FDG和18F-FLT PET/CT检查,分析18F-FDG和18F-FLT标准摄取值(SUV)与肺肿瘤患者的年龄、肿块大小及病理类型等相互关系和统计学意义.结果:18F-FDG和18F-FLT PET/CT的SUV与肺肿瘤患者的年龄、肿块大小均无统计学差异(P＞0.05),18F-FDG PET/CT的SUV与患者的病理类型亦无统计学差异(P＞0.05),而18F-FLT PET/CT的SUV与患者的病理类型有统计学差异(P＜0.05).结论:肺肿瘤患者的肿块病理类型是影响18F-FLT PET/CT的SUV的重要因素,18F-FLT PET/CT的SUV在肺部良恶性肿瘤鉴别诊断中具有重要的价值.