胰腺导管腺癌患者具有较高的腰椎骨髓脂肪含量的影像研究

摘要

目的 探讨胰腺导管腺癌腰椎骨髓脂肪含量的变化.方法 收集32例经MDCT及病理组织学证实的胰腺导管腺癌患者(年龄41~76岁)及32例人口学匹配的健康受试者行MRI水-脂分离成像获取腰椎骨髓脂肪分数(FF),测定血糖、血脂指标(TC、TG、HDL-c、LDL-c)及胰岛素水平.多元Logistic回归分析胰腺导管腺癌的影响因子.结果 胰腺导管腺癌患者FF(67.9%±7.8%)明显高于正常对照组(49.6%±6.5%),且组间血脂指标存在统计学意义(P均<0.05).Logistic回归分析发现,慢性胰腺炎史及FF是胰腺导管腺癌的危险因素,OR值分别为1.304(95%CI为1.102~1.780)及1.521(95%CI为1.115~2.004)(P均<0.01).结论 胰腺导管腺癌患者具有较高腰椎骨髓脂肪含量.%Objective To investigate the change in verertebral marrow fat content of pancreatic ductal adenocarcinoma (PDAC).Methods PDAC patients (41~76 years) and healthy controls (n=32/group) underwent MRI water-fat separation to obtain marrow fat fraction (FF).Ten serum levels of blood glucose, total cholesterol, triglyceride, high density lipoproptein, low density lipoproptein and insulin were measured .Logistic analysis was performed to assess the predictive factors of PDAC .Results The mean FF of PDAC (67.9%±7.8%) was higher than that of controls (49.6%±6.5%).There were significant differences in levels of blood lipids (all P <0.05).Logistic analysis indicated that chronic pancreatitis and FF were independent correlation factors of PDAC (OR=1.304, 95%CI=1.102~1.780 and OR=1.521, 95%CI=1.115~2.004, respectively) (all P <0.01 ) .Conclusion PDAC patients have higher levels of vertebral marrow fat content .