雌二醇对非离子表面活性剂囊泡粒径的影响

摘要

目的：探索雌二醇与胆固醇配比对非离子表面活性剂囊泡粒径的影响。方法选择钙黄绿素作为模型药物，采用薄膜分散法制备非离子表面活性剂囊泡，通过粒径仪测量粒径。结果当胆固醇与雌二醇1∶1、胆固醇用量为0．03g、水化时间1．5h、超声70次（每次3s间隔3s，功率40w）时制备的非离子表面活性剂囊泡粒径最佳，大小为400 nm。结论雌二醇可作为囊泡的膜材料，为开发治疗前列腺炎靶向药物提供了依据。%Objective To explore the effects of ratio of estradiol/cholesterol on the particle size of non-i-onic surfactant vesicles.Methods Calcein was selected as a model drug,non-ionic surfactant vesicles were prepared by thin-film dispersion method,and the particle size was measured by particle size analyzer.Results The results indicated that the optimal size of non-ionic surfactant vesicles was about 400nm,when the ratio of cholesterol/estradiol was 1∶1 with a dosage of 0.03g,the preparation was hydrated for 1.5 h and treated by ultrasound 70 times (3 second each,3 seconds interval) with power of 40w.Conclusion This study dem-onstrated that estradiol may serve as a vesicle membrane materials,and provided a basis for the development of targeted therapies for prostatitis treatment.