女性年龄和获卵数对PESA-ICSI治疗结果的影响

摘要

目的:卵胞质内单精子注射(ICSI)治疗60例阻塞性无精子症患者,分析女方年龄和获卵数对ICSI结局的影响.方法:经皮附睾精子抽吸术(PESA)获得精子,女方进行常规超排卵.分析女方不同年龄组(＜30岁组、30～35岁组和＞35岁组)和不同获卵数组(1～10个组、10～19个组和＞19个组)患者行ICSI后的受精率、卵裂率、胚胎着床率和临床妊娠率的结果.结果:不同年龄组与不同获卵数组的正常受精率、正常卵裂率差异无显著性(P＞0.05),其胚胎着床率差异均有统计学意义(P＜0.05).不同年龄组的临床妊娠率差异显著(P＜0.05),而不同获卵数组的临床妊娠率无统计学差异(P＞0.05).结论:女性年龄和获卵数对PESA-ICSI-ET周期的妊娠结局有明显影响.%Aim; To evaluate the therapy for of 60 cases of obstructive azoospermia treated by intracy-toplasmic sperm injection and to determine the effect of the wife's age and the number of oocytes on the success rates of assisted reproduction. Methods: All patients were undergone sperm retrieval by percutaneous epididymal sperm aspiration ( PESA) while their wives received conventional ovarian hyperstimula-tion. We determined whether the different groups of female age and the number of oocytes have any effect on fertilization, implantation and pregnancy. No significant difference was found in fertilization rate and nomal cleaved embryos rate between the groups of the female age and the number of oocytes (P＞0.05), but the implantation rate was significantly affected by the female age and the number of oocytes (P＜ 0.05 ). The clinical pregnancy rate declined as the age of female partner increased (P＜0.05 ) , but it was not significantly affected by the number of oocytes (P＞0.05 ). Conclusion: The age of the femal partner and the number of ova significantly affected the prognosis of obstructive azoospermia patients.