冠脉宁对麻醉犬脑血流量及脑血管阻力的影响

摘要

目的：了解冠脉宁(GMN)对麻醉犬脑血流量、脑血管阻力、血压、心电图及心率作用的影 响。方法：以犬为实验对象，结扎一侧颈外动脉及枕动脉，以电磁流量计测颈动脉血流量，用多 道生理记录仪记录血压、心电图及心率的变化。结果：冠脉宁(0.4和1.0 g/kg)、步长脑心通胶囊(CBCHNXT，0.64 g/kg)均可明显增 加麻醉犬的脑血流量(P<0.05、P<0.01、P<0.05)及明显降低脑血管阻力( P<0.05)，但对麻醉犬的血压、心电图及心率均无明显影响。结论：冠脉宁通过增加脑血流量和降低脑血管阻力，改善脑血液循环。%Objective:To study the influence of Guanmaining (GMN) on the brain-blood flowin g volume,cerebrovascular resistance,blood pressure and electrocardiogram (ECG) i n anaesthetic dogs.Methods:Using dogs as experimental objects,we ligated one side of carotis extern al artery and occipitalis artery.Electromagnetic flowmeter was used to measure t he blood flowing volume of carotis artery;polygraph system was used to investigate the change of blood pressure,ECG and heart rate.Results:Both GMN (0.4 g/kg,1.0 g/kg) and Capsule Buchangnaoxintong (CBCHNXT) (0. 64 g/kg) could apparently increased the brain-blood flowing volume and reduced the cerebrovascular resistance (P<0.05) in anaesthetic dogs,but they had no ap parent effects on blood pressure,ECG and heart rate.Conclusion:GMN has a certain improving effects on brain blood circulation by inc reasing the brain-blood flowing vlume and reducing the cerebrovascular resistance.