亚急性缺氧大鼠肝、肾中镉、铅含量的变化

摘要

目的：观察大鼠在亚急性缺氧时，机体肝、肾中镉(Cd)、铅(Pb)含量的变化。方法：利用低压舱模拟高原亚急性缺氧条件，将大鼠暴露于7 km高度，停留1．5 h，每日1次；用WFX-Ⅱ型原子吸收分光光度计测定大鼠肝、肾中Cd、Pb的含量。结果：缺氧10 d、20 d组大鼠肝、肾中Cd、Pb含量均明显高于对照组(P＜0．05)，缺氧20 d组肝中Cd、Pb含量和肾中Cd含量均明显高于缺氧10 d组(P＜0．05)。结论：亚急性缺氧环境可引起肝、肾中Cd、Pb含量升高，且随时间延长而持续升高。%Objective:To observe the changes of Cd and Pb in liver and kidney of ratsunder the condition of subacute hypoxin. Methods: Subacute hypoxin environment was simulat-ed in hypobaric chamber and then with rats exposed at an altitude of 7 km(1.5 h/d) once aday,Cd and Pb contents in liver and kidney of rats were determined by WHF-Ⅱ(AAS). Re-sults: Cd and Pb contents in two subacute-hypoxin groups were much higher than those of thecontrol groups(P＜0.05). Cd and Pb contents in liver and Cd content in kidney in 20-daygroup were much higher than those of 10-day group(P＜0.05). Conclusion: Subacute hypoxinenvironment may lead to a significant increase of Cd and Pb contents in liver and kidney, andkeepincreasing with time prolonged.