Objective To discuss the mechanics and biocompatibility characteristics of carbon nanotubes-polyurethane composite membranes. Methods The mechanics property of carbon nanotubes-polyurethane composite membranes with different carbon nanotubes contents were tested by universal material testing machine. The surface of the membranes was observed by electron microscope when the stent was bent 90 degree. And its cytotoxicity was tested by cultivating study with 7721 cell. The metallic stent that was covered with carbon nanotubes-polyurethane composite membrane by using dip-coating method was inserted in rabbit esophagus in order to evaluate its biocompatibility in vivo. Results Composite membranes tensile strength (MPa) and elongation at break (％) were 4.62/900. 6.05/730. 8.26/704 and 5.7/450 when the carbon nanotubes contents were 0％. O.1％. 0.3％ and 0.5％, respectively. If the stent was bent at 90 degree ,its surface was still smooth without any fractures when it was scanned by electron microscope. Composite membranes had critical cytotoxicity when its carbon nanotubes content was up to 0.5％ and l.0％. No fissure nor degradation of composite membranes occurred at 30 days after composite membrane covered metallic stent was inserted in rabbit esophagus. Conclusion When moderate carbon nanotubes are added into polyurethane composite membrane, the mechanics and biocompatibility characteristics of the polyurethane composite membrane can be much improved. (J Intervent Radiol. 2011, 20 : 127-130)%目的 探讨碳纳米管-聚氨酯复合膜的力学特性和生物相容性.方法 将经超声处理的碳纳米管与聚氨酯混合制成复合膜,用万能材料试验机检测不同质量比的复合膜的力学特性,在支架弯曲90°时电镜观察膜的表面,将不同含量的复合膜溶液与人肝癌细胞7721细胞培养进行细胞毒性试验,用浸涂法制备碳纳米管-聚氨酯覆膜金属支架,并置入兔食管进行活体评价.结果 碳纳米管含量为0、0.1%、0.3%和0.5%时,对应的复合膜拉伸强度(MPa)和复合膜断裂延长率(%)分别为:4.62/900、6.05/730、8.26/704、5.7/450.支架弯曲90°,用电镜扫描表面光整,未见裂痕.当碳纳米管含量为0.5%和1.0%时,对细胞生长有明显抑制作用.在兔食管放置30 d后碳纳米管-聚氨酯复合膜未见裂纹、老化降解等现象.结论 添加适量的碳纳米管的聚氨酯膜能改善复合膜的力学特性,同时有较好的生物相容性.
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