肝细胞癌患者射频消融前后的免疫状态研究进展

摘要

After radiofrequency ablation (RFA) treatment,the tumor cells of hepatocellular carcinoma (HCC) will develop coagulation necrosis and apoptosis,producing in situ tumoural antigens which may directly or indirectly stimulate the body's innate and adaptive immune responses to help reverse the body's immune suppression status.This paper aims to make a comprehensive review about the RFA-induced local and systemic immune response,innate immune,adaptive immune and their regulating roles for cytokines in HCC patients,and to further clarify the immune state changes in HCC patients after RFA treatment.%射频消融(RFA)治疗肝细胞癌(HCC)后,肿瘤细胞发生凝固性坏死与凋亡,产生原位肿瘤抗原,直接或间接激发机体固有免疫及适应性免疫反应,帮助逆转机体免疫抑制状态.本文主要对RFA治疗HCC引起的局部及全身性免疫反应、适应性免疫及固有免疫及其对细胞因子的调节发挥的作用进行综述,进而对RFA治疗HCC后的机体免疫改变进行阐明.