The fetal development is closely related with the adverse pregnancy outcomes such as miscarriage, dystocia, congenital malformation, premature baby, low weight baby and so on. It is also a potential predictor of the fetal origin of some adult diseases. Most of the researches on the risk factors affecting fetal development were focused on the mother origin in recent years. The risk factors of father origin can be classified into two groups: the heredity-related factors such as age, diseases, somatotype, lifestyle and environmental exposure which could disturb the integrity of genomics of father origin or the genomic expression; the social and environmental factors such as psychological state, occupation and income which could mainly affect maternal pregnancy environment and life quality. Two kinds of factors can result in abnormal fetal development in uterus, which is related to adverse outcomes of pregnancy. It is benefit for the fetal development and the infant and adult health to offer genetic counseling to those couples with high-risk factors.%胎儿在宫内的生长发育不仅与流产、难产、畸形、早产、低体质量儿等不良妊娠结局密切相关，而且能用于评估成年期罹患某些疾病的风险。近年国内外关于胎儿生长发育的研究大多关注的是母源因素，对父源因素的研究相对较少。父亲影响胎儿发育的主要因素可以分为两类，即包括年龄、疾病、体型、生活方式、暴露环境在内的遗传因素和以心理状态、职业、经济收入为代表的社会环境因素，前者直接影响父源基因的完整性和表达情况，而后者主要影响母体的生活环境和生活质量，这两类因素的不良发展均可能导致胎儿在宫内的生长发育发生异常，从而出现各种不良妊娠结局。
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