体外受精-胚胎移植术后未妊娠患者生育压力与生活质量相关性研究

摘要

目的:探讨体外受精-胚胎移植(IVF-ET)术后未妊娠患者的生育压力与其生活质量的关系.方法:采用患者基本情况调查表、生育压力量表(FPI量表)和生活质量量表(FertiQoL量表)对北京大学第三医院2017年5-10月在生殖医学中心门诊就诊的351例IVF-ET术后未妊娠患者进行横断面调查,其中移植次数≥3次未妊娠患者为104例、移植次数＜3次未妊娠患者为247例,描述接受IVF-ET术后未妊娠患者生育压力和生活质量的现状,评价其生育压力、生活质量,探讨两者的相互关系.结果:IVF-ET术后未妊娠患者FPI总分为(162.22±20.63)分,FertiQoL总分为(58.79±12.79)分.移植次数≥3次未妊娠患者与移植次数＜3次未妊娠患者FPI总分和各分项得分、FertiQoL总分和各分项得分比较,差异均无统计学意义(均P＞0.05).Pearson相关分析结果显示,IVF-ET术后未妊娠患者FPI中无子女压力得分与FertiQoL总分呈正相关(P＜0.05),FPI其他项目得分与FertiQoL总分呈负相关(均P＜0.05).多重线性回归结果显示,生育压力、年龄和文化程度是IVF-ET术后未妊娠患者生活质量的重要影响因素(F=9.140,R2=0.391,P＜0.01).结论:IVF-ET术后未妊娠患者的生育压力是其生活质量重要的影响因素,其生育压力越大,生活质量越低,应重视移植后未妊娠给患者造成的心理压力,采取积极有效的措施,提高IVF-ET移植后未妊娠患者的生活质量.%Objective:To investigate the relationship between fertility stress and life quality in non-pregnant patients undergoing IVF-ET.Methods:The cross-sectional survey was carried out by studying the basic situation,the Fertility Question Inventory (FPI) scale and the Fertility Quality of Life (FertiQoL) scale among 351 non-pregnant patients with IVF-ET failures in our center from May 2017 to October 2017,including 104 non-pregnant patients underwent more than 3 times of transplantation and 247 non-pregnant patients underwent less than 3 times of transplantation.The fertility stress and life quality was described by FPI and FertiQoL,respectively.The correlation between fertility stress and life quality was explored using Pearson method.Results:The total score of FPI in non-pregnant patients underwent IVF-ET was 162.22±20.63,and the total score of FertiQoL was 58.79±12.79.There were no significant differences in the FPI total scores and sub-item score,and FertiQoL total score and sub-item score,between patients being transplanted more than 3 times and patients being transplanted less than 3 times (all P＞0.05).Pearson analysis showed that there was positive correlation between the childless stress score in FPI and the total score in FertiQoL (P＜0.05),and that there was negative correlation between other item score in FPI and the total score in FertiQoL (P＜0.05).Multiple linear regression analysis showed that fertility stress,age and literacy were the main factors of the life quality in patients with IVF-ET failures (F=9.140,R2=0.391,P＜0.01).Conclusions:The fertility stress of non-pregnant patients underwent IVF-ET is an important factor influencing the life quality.The greater the fertility stress,the lower the life quality.Should pay attention to the psychological pressure in those non-pregnant patients underwent IVF-ET failures,and improve their life quality by proactively releasing the fertility stress.