人参皂苷Rg3剂型的研究进展

摘要

人参皂苷Rg3作为人参中的有效活性成分,抗肿瘤作用明显,能有效抑制肺癌、胃癌、肝癌、肠癌和乳腺癌的发展,提高机体免疫力.人参皂苷Rg3单体水溶性差、口服吸收慢、消除快、血药浓度和生物利用度低,因此如何克服其溶解度低,改善其生物利用度成为研究的重要方向.本文通过查阅相关文献,综述了人参皂苷Rg3的剂型研究.%Ginsenoside Rg3,the active ingredient of ginseng with obvious anti-tumor effect,can effectively inhibit the growth of lung cancer,gastric cancer,liver cancer,colon cancer and breast cancer,and improve the immunity. However,ginsenoside Rg3 has poor water solubility with slow absorption and rapid elimination,which leads to low plasma concentration and low bioavailability. Thus,how to overcome its low solubility and improve its bioavailability has become an important research area. In this paper ,the dos-age forms of ginsenoside Rg3 are reviewed by consulting relevant publications.