子宫内膜异位症发生中的凋亡异常

摘要

子宫内膜异位症(EMs)是一种具有侵袭、血管形成、复发等恶性行为的常见妇科良性疾病,但其发病机制尚不清楚.细胞凋亡是基因控制的细胞程序性死亡,不仅对于维持自身稳态及生理功能至关重要,还参与肿瘤的发生及发展.近年发现EMs患者的在位内膜及异位内膜存在凋亡异常,并通过相关通路导致疾病的发生与发展.综述EMs患者存在的影响凋亡发生的因素,以期通过调控凋亡发生的相关因素达到治疗目的.%Endometriosis is a common benign gynecologic disease which is characterized by invasion,vascularization,recurrence and other malignant behaviors,while the exact pathogenic mechanisms of endometriosis remain unsolved.Apoptosis is recognized as a programmed cell death controlled by specific genes.It plays an important role in maintaining tissue homeostasis and eliminating excess or dysfunctional cells,which also involves in the development of various cancers.Recently,reduction in apoptosis has been observed in both eutopic and ectopic endometrium of women with endometriosis and leads to the development of endometriosis through related pathways.It reviews the recent literatures focused on the influencing factors of apoptosis in endometriosis and expects to find a new therapy to control this possible factors.