以多巴胺(DA)为模板,氨基修饰的介孔硅为载体,制得对多巴胺具有特异选择性的表面分子印迹聚合物(MIP).将所得的MIP制成碳糊电极,用循环伏安法对多巴胺进行检测.在优化实验条件下,传感器的氧化峰电流与多巴胺浓度在1.0×10-7～2.0×10-6 mol/L和2.0×10-6～1.0 × 10-4 mol/L范围内呈良好的线性关系,相关系数分别为0.9925和0.9969,检出限为1.3×10-9 mol/L.该传感器对DA具有较高的灵敏度和选择性,将其用于实际样品检测,结果满意.%A molecularly imprinted polymer ( MIP), which has a specific selectivity to dopamine, was synthesized using dopamine as template and 3-aminopropyltriethoxysilane modified mesoporous silica as carrier. The MIP was used to fabricate a sensor for the determination of dopamine, which response to dopamine( DA) was evaluated by cyclic voltammetry. Under the optimized conditions, the sensor displayed good linearities in the ranges of 1.0 × 10-7 -2.0 × 10 -6 mol/L and 2.0 × 10-6 -1.0 ×10-4 mol/L with a lower detection limit of 1.3 ×10 ~9 mol/L. The correlation coefficients were 0.992 5 and 0.996 9, respectively. The studied imprinted sensor exhibited high sensitivity and selectivity, and was successfully applied in the determination of dopamine in human blood plasma.
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