Correlation between the Expression of Aquaporin 1 and Hypoxia-inducible Factor 1 in Breast Cancer Tissues

摘要

The correlation between aquaporin 1(AQP1) and hypoxia-inducible factor 1(HIF 1) in breast cancer tissues was preliminarily studied.In 155 cases of breast cancer,the expression levels of AQP1 were detected by immunohistochemisty in HIF1-positive group or HIF1-negative group,and the correlation between AQP1 and HIF1 was analyzed.The overexpression of AQP1 and HIF1 were observed in 155 cases of breast cancer tissues.The expression level of AQP1 in HIF1-positive group was significantly higher than that in HIF1-negative group.The positive expression rate of AQP1 was 296.55±24.67 and 168.37±37.53 in HIF1-positive group and HIF1-negative group respectively with the difference being very significant between them(P<0.001).It was concluded that AQP1 was overexpressed in the HIF1-positive group and there were some correlations between AQP1 and HIF1,suggesting they interact each other and regulate the oncogenesis of breast cancer.