In Vivo Histocompatibility Evaluation of Polyurethane Membrane Modified by Superfine Silk-fibroin Powder

摘要

In this study,a novel polyurethane membrane,modified by superfine silk-fibroin powder, was prepared for small-diameter vascular grafting.Scanning electron microscopy,transmission electron microscopy,and histological examination were applied to evaluate histocompatibility of this polyurethane membrane.The polyurethane membrane was compared with polytetrafluoroethylene material.A pseudomembrane and gap formed between polytetrafluoroethylene and the surrounding tissues,and no cells infiltrated or grew into the polytetrafluoroethylene material.On the contrary,superfine silk-fibroin powder/polyurethane blend membrane merged tightly with the surrounding tissues without gaps,and cells infiltrated and grew into the material.Moreover,the negative effects of superfine silk-fibroin powder/polyurethane blend membrane on cells were less than those of its polytetrafluoroethylene counterpart.Our findings indicated that the superfine silk-fibroin powder/polyurethane blend membrane has better histocompatibility than polytetrafluoroethylene mem- brane.It is concluded that the superfine silk-fibroin powder/polyurethane blend membrane is a promising biomaterial for small-diameter prosthesis.