为了探讨抗菌肽对断奶仔猪生产性能和健康水平的影响，选取144头（25±3）日龄、体质量相近[（6．91±1．10） kg ]的杜×长×大三元杂交断奶仔猪，随机分成3组，即基础日粮组（对照组）、基础日粮＋0.2％抗菌肽组（试验1组）和基础日粮＋0.4％抗菌肽组（试验2组），试验周期28d，测定其生产性能和血清相关指标的变化。结果显示，与对照组相比，试验前期（1～14 d ）试验2组仔猪平均日增体质量、平均日采食量和料重比分别提高11.3％、3.8％和6.4％，但组间差异不显著。试验1组和试验2组死淘率显著降低，试验2组的血清IgG和血清总胆固醇显著高于对照组、尿素氮显著低于其他组。另外，试验1组和试验2组血清丙二醛含量显著低于对照组，试验2组的抗氧化能力显著高于对照组和试验1组。表明抗菌肽能显著改善断奶仔猪的生产性能，提高血清Ig G水平、抗氧化性能和健康水平，降低死淘率。%In order to study the effect of antimicrobial peptide on grow th performance and health of weaning piglets ,144 weaning piglets [(25 ± 3) d of age ,Landrace × Yorkshire × Duroc ,initial body weight :(6 .91 ± 1 .10)kg] were randomly allotted to 3 treatments .There were 3 replicate pens in each treatment with 16 pigs per pen .The dietary treatments were basal diet (control) , basal diet + 0 .2% antimicrobial peptide (group 1 ) and basal diet + 0 .4% antimicrobial peptide (group 2) .The experimental diets were fed in for 2 phases(1-14 d ,prior phase and 15-28 d ,la-ter phase post-weaning) .The growth performance and serum related indices of 3 treatments were measured .The results showed that ADG ,ADFI and F/G of the piglets in group 2 were increased by 11 .3% ,3 .8% and 6 .4% ,but difference between the group 2 and control was not significant . The death and culling rates of the piglets in group 1 and group 2 were significantly lower than that of control ,the serum IgG and TC content of group 2 were significantly higher ,and the serum BUN level was significantly lower than that of group 1 and control .In addition ,the serum MDA content in group 1 and 2 was significantly lower than that of control ,and the serum T-AOC activi-ty in group 2 was significantly higher than that of goups 1 and control .It can be inferred that the serum IgG level ,antioxidant capacity and health of the weaning piglets could be significantly im-proved with antimicrobial peptide supplementation in the diets ,and the death and culling rate re-duced as w ell .
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