FGF+Collagen联合百多邦治疗烧伤后残余创面对炎性因子表达及创面愈合的影响

摘要

目的 探讨成纤维细胞生长因子(fibroblast growth factor,FGF)+胶原蛋白(Collagen)联合百多邦治疗烧伤后残余创面对炎性因子表达及创面愈合的影响.方法 80例患者随机分为对照组和观察组各40例.对照组给予百多邦治疗,观察组给予创必复(FGF+Collagen)生物蛋白海绵联合百多邦治疗.比较2组临床疗效、创面修复情况、炎症因子表达水平以及创面愈合质量.结果 观察组临床疗效和总有效率明显优于或高于对照组(P<0.05).观察组肉芽组织生长良好率、细菌培养阴性率、创面细菌清除率均明显高于对照组,而肉芽组织生长时间、创面愈合时间以及视觉模拟评分明显低于对照组(P<0.05).观察组色素沉着、瘢痕增生、创面加深以及创面感染等发生率明显低于对照组(P<0.05).治疗前,2组创面IL-1β和TNF-α表达水平差异均无统计学意义(P>0.05);治疗后14 d,2组创面IL-1β和TNF-α表达水平均较治疗前明显降低,但观察组较对照组下降更明显(P<0.05).结论 FGF+Collagen联合百多邦治疗烧伤后残余创面疗效显著,能够有效促进创面愈合,减轻瘢痕增生,降低创面炎症因子表达,抑制细菌生长,从而减少或避免创面感染的发生,值得临床推广应用.%Objective To explore the impact of fibroblast growth factor(FGF)+ Collagen combined with Bactroban on the expression of the inflammatory factors and wound healing in the treatment of residual burn wounds.Methods Eighty patients were randomly divided into the control group(n =40)and the observation group(n =40).Bactroban was applied in the control group,while FGF+Collagen biologic protein sponge combined with Bactroban were applied in the observation group.The clinical efficacy,wound repair,the expression of the inflammatory factors and the quality of wound healing of the two groups were compared.Results The total effective rate of the observation group was obviously higher than that of the control group,the difference was statistically significant (P< 0.05 ).Good rate of granulation tissue growth, negative rate of bacterial culture,clearance rate of the wound bacterial of the observation group were obviously higher than those of the control group,while granulation tissue growth time, wound healing time and Visual Analogue Scale (VAS) score of the observation group were obviously lower than those of the control group,differences were statistically significant (P<0.05).The incidence rates of pigmentation,scar hyperplasia,deepening and the infection of the wound of the observation group were obviously lower than those of the control group,differences were statistically significant(P<0.05).Before treatment,there were no significant differences of the expression of IL-1β and TNF-α between the two groups (P> 0.05 ),and 14 days after treatment,the expression of IL-1βand TNF-αof the two groups were obviously lower,and those of the observation group were much lower than those of the control group,differences were statistically significant (P< 0.05 ).Conclusion FGF + Collagen combined with mupirocin ointment in treating residual burn wounds has significant curative effect,which may effectively promote wound healing,prevent the scar hyperplasia.FGF+Collagen combined with Bactroban helps to inhibit bacterial growth by reducing the expression of wound inflammation factors,so as to reduce and avoid the incidence of wound infection.It is worthy of clinical application.