槲寄生中N-桂皮酰基丁二胺药代动力学研究

摘要

研究槲寄生中N-桂皮酰基丁二胺在大鼠体内的药代动力学特点.大鼠灌胃给予N-桂皮酰基丁二胺,采集不同时间点的大鼠血浆,用HPLC法检测大鼠血浆中N-桂皮酰基丁二胺的浓度,并用DAS2.0药动学软件进行数据处理,计算药动学参数.N-桂皮酰基丁二胺在大鼠体内的药动学特征符合一室模型,药动学参数分别为:半衰期速率常数T1/2(ka)=0.343 h,分布半衰期T1/2=1.306 h,达峰时间Tmax=0.750 h,最大血药浓度Cmax=1.700μg/mL,表观分布容积V1/F=21.047 L·kg-1,口服消除率CL=11.172 L·h-1·kg-1,药时曲线下面积AUC(0-t)=4.129 h·mg·L-1.N-桂皮酰基丁二胺口服给药后,吸收和分布均较快,且分布广泛,在血浆中的清除也较快.%To study the pharmacokinetic character of N-cinnamoyl putrescine in rats, after the rats were administered by N-cinnamoyl putrescine through ig, HPLC was used to deter-mine the concentration of N-cinnamoyl putrescine in blood plasma at different times, phar-macokinetic software DAS2.0 was used to process the data.N-cinnamoyl putrescine was shown to be one-room distribution model in rats.The main pharmacokinetic parameters of N-cinnamoyl putrescine are as follows:T1/2(ka) =0.343 h, T1/2 =1.306 h, Tmax =0.750 h, Cmax=1.700 μg· mL-1 , V1/F =21.047 L· kg-1 , CL =11.172 L· h-1 · kg-1 , AUC (0-t) =4.129 h· mg· L-1 .It indicated that the absorption and distribution of N-cin-namoyl putrescine was rapid and wide.The distribution was broad and clearance was very quick in the plasma.