A zebrafish ( Danio rerio ) model was applied to evaluate the developmental toxicity of short⁃chain chlorinated paraffins ( SCCPs) . Death rates, hatching rates, malformation rates and body length were observed after the zebrafish embryos were exposed to different concentrations of C10(50.2% Cl) separately for 24, 48, 72 and 96 h. The results indicated that C10(50.2% Cl) could exert lethal and sub⁃lethal effects on the early life stage of zebrafish. Higher concentrations of C10(50.2% Cl) ( 1 000 and 10 000 μg/L) could not only cause significant death rates increase to 100% after 96 h exposure and hating delay after 48 h exposure, but also induce a series of malformations, including spinal curvature, yolk deformity, pericardial edema, malformation of tail and uninflated swim bladder. Since the growth inhibition of juvenile zebrafish caused by C10 ( 50. 2% Cl ) on the exposure concentrations no matter high or low, SCCPs might be a risk to the aquatic ecology and fish development.%为评价短链氯化石蜡对斑马鱼胚胎的发育毒性，以斑马鱼为模式生物，观察不同质量浓度的短链氯化石蜡C10（50．2％ Cl）暴露24，48，72和96 h后斑马鱼胚胎／幼鱼的死亡率、孵化率、畸形率和体长．结果表明，C10（50．2％ Cl）在斑马鱼的早期发育阶段可引起一系列非致死效应和致死效应．高质量浓度（1000和10000μg／L）短链氯化石蜡可导致96 h斑马鱼胚胎死亡率显著升高（达100％），48 h抑制胚胎的孵化，并诱发一系列的发育畸形．C10（50．2％ Cl）在斑马鱼幼鱼中引起的畸形表型主要包括脊柱弯曲，卵黄畸形，心包囊肿，尾部畸形和鱼鳔发育缺陷．低质量浓度组和高质量浓度组C10（50．2％ Cl）均能够抑制斑马鱼幼鱼的生长速度，目前的环境质量浓度已具有一定程度的水生生态风险．
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