病毒性心肌炎患儿的心率减速力与心肌损伤程度的相关性研究

摘要

目的：：发现病毒性心肌炎患儿的心率减速力与心肌损伤程度的相关性。方法：90例病毒性心肌炎患儿及86例健康儿童作为研究对象,对比两组儿童的心率减速力、心肌损伤程度指标差异,进一步分析心率减速力与心肌损伤程度的相关关系。结果：观察组患者的平均 DC 水平,心率变异性指标SDNN、SDANN、RMSSD、LF、HF 水平低于对照组儿童；血清心肌酶谱指标 CK、CK-MB、cTn Ⅰ、LDH、AST、ALT 含量高于对照组儿童；血清凋亡指标 GrB、sFasL、Bax、caspase-3含量高于对照组儿童,Bcl-2含量低于对照组儿童；心脏运动速度指标 MSV1、MSV2、MSV3、PFVe、PFVa 水平低于对照组儿童。病毒性心肌炎患儿的心率减速力与心率变异性、心肌酶谱、心肌凋亡、心脏运动等心肌损伤相关指标均存在直接相关关系。结论：病毒性心肌炎患儿的心率减速力改变与心肌损伤具有直接相关关系,可以作为患儿病情严重程度判断、临床治疗指导的可靠媒介。%Objective:To find the correlation between deceleration capacity of rate and myocardial injury degree in chil-dren with viral myocarditis.Methods:A total of 90 children with viral myocarditis and 86 healthy children were selected as the research subjects,differences in rate deceleration capacity of rate and myocardial damage degree indexes were compared be-tween two groups of children,and the correlation between deceleration capacity of rate and myocardial injury degree was fur-ther analyzed.Results:Mean DC level as well as heart rate variability indexes SDNN,SDANN,RMSSD,LF and HF levels of observation group was lower than those of control group;serum myocardial enzyme spectrum indexes CK,CK-MB,cTnⅠ, LDH,AST and ALT content were higher than those of control group;serum apoptosis indexes GRBS,sFasL,Bax and caspase-3 content were higher than those of control group while Bcl-2 content was lower than that of control group;heart rate indexes MSV1,MSV2,MSV3,PFVe and PFVa levels were lower than those of control group.Deceleration capacity of rate in children with viral myocarditis was directly correlated with myocardial injury-related indexes such as heart rate variability,my-ocardial enzyme spectrum,myocardial apoptosis and heart rate.Conclusions:The change of deceleration capacity of rate in chil-dren with viral myocarditis is directly correlated with myocardial injury,and can be used as a reliable medium for disease sever-ity judgment and clinical treatment guidance.