老年湿疹患者 Th 1/Th2细胞因子的血清水平与湿疹的发展及其临床表现的相关性

摘要

Objective:To investigate variations of Th1/Th2 cytokine levels,as well as their correlation with eczema de-velopment and clinical manifestation in aged patients.Methods:A total of 92 patients (above 60 years old)with eczema diag-nosed by the outpatient department of dermatology and venerology of our hospital were included as the eczema group,while 60 aged patients without eczema as the healthy group.Patients'serum levels of Th1/Th2 cytokines were examined for inter-group comparison and stratified analysis as per clinical manifestation.Results:Serum levels of interleukin (IL)-2,IL-4,IL-10,IL-12,tumor necrosis factor (TNF)-ɑand interferon (IFN)-γwere all significantly higher in patients of the eczema group than the healthy group (P <0.05).Acute stage levels of IL-2,IL-4,IL-10 and IFN-γwere significantly higher in patients of the eczema group than the healthy group (P <0.05).There was no significant difference in the levels of IL-12 and TNF-ɑbetween patients of the acute stage and those of the chronic stage (P >0.05).And no significant difference existed in the levels of IL-2,IL-4, IL-10,IL-12,TNF-ɑand IFN-γbetween generalized and localized eczema patients (P >0.05).Conclusion:Compared with the healthy population,Th1/Th2 cytokine levels are significantly different in eczema patients,especially those in the acute stage.%目的：：研究分析老年湿疹患者 Th1/Th2细胞因子的水平变化与患者疾病发展及临床表现的关系.方法：选取本院皮肤性病门诊确诊的60岁以上的老年人92例(湿疹组)和60例健康老年人(健康组)作为研究对象，检测两组血清 Th1/Th2细胞因子水平并进行比较，并根据患者临床表现进行分层分析.结果：湿疹组患者的 IL-2、IL-4、IL-10、IL-12、TNF-ɑ、IFN-γ水平均显著的高于健康组人群且差异均具有统计学意义(P ＜0．05)；湿疹组急性期患者的 IL-2、IL-4、IL-10、IFN-γ水平均显著的高于健康组人群且差异均具有统计学意义(P ＜0．05)；急性期与慢性期湿疹患者的 IL-12、TNF-ɑ水平差异无统计学意义(P ＞0．05).湿疹组患者泛发性和局限性的 IL-2、IL-4、IL-10、IL-12、TNF-ɑ、IFN-γ水平均差异均不具有统计学意义(P ＞0．05).结论：湿疹患者的 Th1/Th2细胞因子的水平发生显著的改变较正常人群，尤其是急性期患者改变更为显著.