有氧运动训练对AD患者胰岛素抵抗、血脂代谢及炎症反应的影响

摘要

Objective: To study the effect of aerobic exercise training on insulin resistance, lipid metabolism and inflammatory response in patients with Alzheimer's disease (AD).Methods: A total of 84 patients who were diagnosed with Alzheimer's disease in the Mental Health Center in Zigong City between June 2014 and December 2016 were selected and randomly divided into aerobic exercise group and normal control group who received aerobic exercise intervention combined with conventional drug therapy and conventional drug therapy respectively.The insulin resistance indexes, blood lipid metabolism indexes and inflammatory response indicators were detected before intervention as well as 3 months and 6 months after intervention.Results: Three months and six months after intervention, the HOMA-IR levels as well as serum TC, LDL-C, ApoB, TNF-α, MCP-1, MIA-1α and HMGB1 contents of aerobic exercise group were significantly lower than those before intervention (P<0.05) while HOMA-β, ISIcomp and MBCI levels as well as serum HDL-C and ApoAI contents were significantly higher than those before intervention (P<0.05);the HOMA-IR, HOMA-β, ISIcomp and MBCI levels as well as serum TC, LDL-C, HDL-C, ApoAI, ApoB, TNF-α, MCP-1, MIA-1α and HMGB1 contents of normal control group were not statistically different from those before intervention (P>0.05).Conclusion: Aerobic exercise training can improve insulin resistance and blood lipid metabolism, and inhibit inflammatory response in patients with AD.%目的:研究有氧运动训练对阿尔茨海默病(AD)患者胰岛素抵抗、血脂代谢及炎症反应的影响.方法:选择2014年6月~2016年12月在自贡市精神卫生中心诊断为阿尔茨海默病的84例患者,并随机分为有氧运动组、常规对照组,分别接受有氧运动干预联合常规药物治疗、常规药物治疗,干预前及干预后3、6个月时,检测胰岛素抵抗指标、血脂代谢指标、炎症反应指标.结果:干预后3、6个月时,有氧运动组患者胰岛素抵抗指数(HOMA-IR)水平以及血清中总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(ApoB)、肿瘤坏死因子(TNF)-α、单核细胞趋化蛋白(MCP-1)、MIA-1α、高迁移率族蛋白B1(HMGB1)的含量显著低于干预前(P<0.05),胰岛β细胞功能指数(HOMA-β)、混合胰岛素敏感度(ISIcomp)、胰岛β细胞功能指数(MBCI)水平以及血清高密度脂蛋白胆固醇(HDL-C)、ApoAI的含量显著高于干预前(P<0.05);常规对照组患者HOMA-IR、HOMA-β、ISIcomp、MBCI水平以及血清TC、LDL-C、HDL-C、ApoAI、ApoB、TNF-α、MCP-1、MIA-1α、HMGB1的含量与干预前比较无统计学差异(P>0.05).结论:有氧运动训练用于AD患者能够改善胰岛素抵抗、血脂代谢并抑制炎症反应程度.