冠心病患者血清中PDGF、Ang-2含量与动脉粥样斑块特征的相关性研究

摘要

Objective: To study the correlation of serum PDGF and Ang-2 contentwith atherosclerotiplaque featurein patientwith coronary heardisease.Methods: total of 80 patientwith coronary heardisease who were treated in ouhospital between January 2013 and April 2016 were collected athe observation group, and 50 healthy subjectwho received medical examination in ouhospital during the same period were selected athe normal control group.Serum PDGF and Ang-2 contentof two groupof patientwere detected, and the observation group were furthedivided into the high PDGF group and low PDGF group (n=40) awell athe high Ang-2 group and low Ang-2 group (n=40) according to the median of PDGF and Ang-2 contents.Ultrasonicontrastechnology waused to assesthe atherosclerotiplaque characteristicin patientwith coronary heardisease.Results: Serum PDGF and Ang-2 contentof observation group were significantly highethan those of control group;ultrasound parameterP and AUlevelof high PDGF group were highethan those of low PDGF group while Tp and MTlevelwere lowethan those of low PDGF group;ultrasound parameterP and AUlevelof high Ang-2 group were highethan those of low Ang-2 group while Tp and MTlevelwere lowethan those of low Ang-2 group.Conclusions: Serum PDGF and Ang-2 contentincrease in patientwith coronary heardisease and are negatively correlated with the atherosclerotiplaque stability.%目的:研究冠心病患者血清中PDGF、Ang-2含量与动脉粥样斑块特征的相关性.方法:收集本院收治的冠心病患者80例作为观察组,同期在本院进行体检的健康人群50例作为正常对照组.检测两组血清中PDGF、Ang-2的含量,其中观察组以PDGF、Ang-2含量中位数进一步分为高PDGF组、低PDGF组,高Ang-2组、低Ang-2组各40例.采用超声造影技术评估冠心病患者的动脉粥样斑块特征.结果:观察组血清中PDGF、Ang-2的含量均显著高于对照组;高PDGF组超声参数P、AUC水平高于低PDGF组,Tp、MTT水平低于低PDGF组;高Ang-2组超声参数P、AUC水平高于低Ang-2组,Tp、MTT水平低于低Ang-2组.结论:冠心病患者血清中PDGF、Ang-2含量增加且与动脉粥样斑块稳定性呈负相关.