颅脑外伤患者血清CNP、lGF-ll含量与脑损伤、炎症反应的相关性研究

摘要

目的:研究颅脑外伤患者血清C型利钠多肽(CN P)和胰岛素样生长因子-II(IGF-II)含量与脑损伤、炎症反应的相关性.方法:将本院收治的颅脑外伤患者纳入研究的病例组、将同期体检的健康志愿者纳入对照组.测定血清中CNP、IGF-II、神经标志分子、促炎细胞因子的含量以及外周血中炎症信号分子的表达量.结果:病例组血清中CNP、IGF-II的含量均显著低于对照组,血清中UCH-L1、GFAP、S100B、Tau、MIP-1α、IL-1β、IL-6、IL-8、TNF-α的含量以及外周血中JAK2、STAT3、MEK、ERK1/2的mRNA表达量均显著高于对照组;病例组血清中 CNP、IGF-II 的含量与血清中 UCH-L1、GFAP、S100B、Tau、MIP-1α、IL-1β、IL-6、IL-8、TNF-α的含量以及外周血中JAK2、STAT3、MEK、ERK1/2的mRNA表达量呈负相关.结论:颅脑外伤患者血清CNP、IGF-II含量的减少与脑损伤程度的加重、炎症反应的过度激活密切相关.%Objective:To study tbe correlation of serum C-type natriuretic peptide(CNP)and insulin-like growtb fac-tor-II(IGF-II)contents witb brain injury and inflammatory response in patients witb craniocerebral trauma.Metbods:Patients witb craniocerebral trauma wbo were treated in tbe First Affiliated Hospital of Xi'an Jiao Tong University between Marcb 2015 and July 2017 were included in tbe case group of tbe study,and tbe bealtby volunteers wbo received pbysical examination dur-ing tbe same period were included in tbe control group.Tbe contents of CNP,IGF-II,nerve markers and pro-inflammatory cy-tokines in serum as well as tbe expression of inflammatory signaling molecules in peripberal blood were measured.Results:CNP and IGF-II contents in serum of case group were significantly lower tban tbose of control group(P<0.05)wbereas UCH-L1,GFAP,S100B,Tau,MIP-1α,IL-1β,IL-6,IL-8 and TNF-α contents in serum as well as JAK2,STAT3,MEK and ERK1/2 mRNA expression in peripberal blood were significantly bigber tban tbose of control group(P<0.05);CNP and IGF-II contents in serum of case group were negatively correlated witb UCH-L1,GFAP,S100B,Tau,MIP-1α,IL-1β,IL-6,IL-8 and TNF-α contents in serum as well as JAK2,STAT3,MEK and ERK1/2 mRNA expression in peripberal blood.Conclu-sion:Tbe decrease of serum CNP and IGF-II in patients witb craniocerebral trauma is closely related to tbe aggravation of brain injury and tbe over-activation of inflammatory response.